Amiodarone-Induced Neonatal Hypothyroidism: A Unique Form of Transient Early-Onset Hypothyroidism

Amiodarone-Induced Hypothyroidism Presenting as Cardiorenal Syndrome

Here we present the case of a 90-year-old man with chronic heart and renal failure who was admitted with what appeared to be a simple heart failure exacerbation. However, further investigation led to the diagnosis of profound amiodarone-induced hypothyroidism as the cause of his acute decompensation, highlighting the importance of a broad differential diagnosis and thorough investigation.

Transient neonatal-onset hypothyroidism boosts estradiol synthesis in the testis of adult Wistar rat

Mammalian testis is a target organ for thyroid hormones (Jannini et al., 1995; Aruldhas, 2002). Testis is an exocrine organ because it produces sperm and it is also an endocrine organ producing hormones (MendisHandagama, 2012). Histologically, the testis consists of three major cell types: Leydig cell (LCs) (steroidogenic cells), Sertoli cells (SCs) (nursery cells) and germ cells (GCs). LCs lie...

Transient hypothyroidism induced by anticonvulsant agents.

The question whether antiepileptic drugs alter thyroid function requires a better understanding. In our article, we report two sisters, one of whom was treated with levothyroxine because of hypothyroidism. Although both women received anticonvulsant therapy, transient hypothyroidism was observed only in the hypothyroid woman and was found after treatment with classic anticonvulsant agents (carb...

Contribution of genetic factors to neonatal transient hypothyroidism.

BACKGROUND The causes of neonatal transient hypothyroidism (NTH) remain incompletely understood. Whether it is influenced by genetic background is rarely discussed and remains unproven. A defect in thyroid peroxidase is a common cause of dyshormonogenesis of the thyroid gland in Taiwanese, with a novel mutation (2268insT) present in nearly 90% of alleles studied. OBJECTIVE To determine if the...

Congenital hypothyroidism and neonatal jaundice.